منابع مشابه
The possible viral aetiology of disseminated sclerosis.
The two most attractive current hypotheses concerning the aetiology of disseminated (multiple) sclerosis (MS) are those of (1) an 'autoimmune' process, analogous to experimental allergic encephalitis, or (2) an infection, for which the 'slow virus diseases' of the central nervous system represent a possible model. Experimental data have been advanced favouring each hypothesis, and it is in fact...
متن کاملAetiology and pathogenesis of acute sporadic disseminated encephalomyelitis and multiple sclerosis.
THE investigation of nervous diseases caused by viruses requires close co-operation between clinical and experimental workers. The present paper is the summary of such co-operative work performed by a neuro-histologist and a team of workers in virus diseases. Its chief purpose is to throw some light upon the etiology and pathogenesis ofacute disseminated encephalomyelitis and multiple sclerosis...
متن کاملPrevalence of Disseminated Sclerosis
CHARCOT remarked in 1868: "Even today I do not believe that disseminated sclerosis is known in England," and this may have been true, although Moxon described a case in 1873 and others some years later. Williamson (1903) reported a proportion of patients with disseminated sclerosis equivalent to 27 cases for every 1,000 nervous diseases seen at the Manchester Royal Infirmary over a period of 10...
متن کاملFamilial Incidence of Disseminated Sclerosis
IN Northern Ireland we have recently completed a survey of disseminated sclerosis; 700 cases have been traced and examined and in 44 families we have found more than one member affected, giving a familial incidence of 6.58 per cent.; this figure corresponds closely with the incidence in recent surveys from the Middlesex Hospital 6.5 per cent. (Pratt, et al., 1951), and from the Bristol area 6 p...
متن کاملThe complex genetic aetiology of multiple sclerosis.
A large body of immunologic, epidemiologic, and genetic data indicate that tissue injury in multiple sclerosis (MS) results from an abnormal immune response to one or more myelin antigens that develops in genetically susceptible individuals after exposure to an as-yet undefined casual agent. A genetic component in MS is indicated by an increased relative risk to siblings compared to the general...
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ژورنال
عنوان ژورنال: BMJ
سال: 1959
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5137.1588-c